Server-side Rescoring of Spoken Entity-centric Knowledge Queries for Virtual Assistants

On-device Virtual Assistants (VAs) powered by Automatic Speech Recognition (ASR) require effective knowledge integration for the challenging entity-rich query recognition. In this paper, we conduct an empirical study of modeling strategies for server-side rescoring of spoken information domain queries using various categories of Language Models (LMs) (N-gram word LMs, sub-word neural LMs). We investigate the combination of on-device and server-side signals, and demonstrate significant WER improvements of 23%-35% on various entity-centric query subpopulations by integrating various server-side LMs compared to performing ASR on-device only. We also perform a comparison between LMs trained on domain data and a GPT-3 variant offered by OpenAI as a baseline. Furthermore, we also show that model fusion of multiple server-side LMs trained from scratch most effectively combines complementary strengths of each model and integrates knowledge learned from domain-specific data to a VA ASR system

Investigating techniques for low resource conversational speech recognition

International audienceIn this paper we investigate various techniques in order to build effective speech to text (STT) and keyword search (KWS) systems for low resource conversational speech. Sub-word decoding and graphemic mappings were assessed in order to detect out-of-vocabulary keywords. To deal with the limited amount of transcribed data, semi-supervised training and data selection methods were investigated. Robust acoustic features produced via data augmentation were evaluated for acoustic modeling. For language modeling, automatically retrieved conversational-like Webdata was used, as well as neural network based models. We report STT improvements with all the techniques, but interestingly only some improve KWS performance. Results are reported for the Swahili language in the context of the 2015 OpenKWS Evaluation

Experiência inicial de um hospital universitário utilizando a telemedicina na promoção de educação através de vídeo-conferências

Telehealth and telemedicine services are advancing rapidly, with an increasing spectrum of information and communication technologies that can be applied broadly to the population's health, and to medical education. The aim here was to report our institution's experience from 100 videoconferencing meetings between five different countries in the Americas over a one-year period. Retrospective study at Universidade Estadual de Campinas. Through a Microsoft Excel database, all conferences in all specialties held at our institution from September 2009 to August 2010 were analyzed retrospectively. A total of 647 students, physicians and professors participated in telemedicine meetings. A monthly mean of 8.3 (± 4.3) teleconferences were held over the analysis period. Excluding holidays and the month of inaugurating the telemedicine theatre, our teleconference rate reached a mean of 10.3 (± 2.7), or two teleconferences a week, on average. Trauma surgery and meetings on patient safety were by far the most common subjects discussed in our teleconference meetings, accounting for 22% and 21% of the total calls. Our experience with telemedicine meetings has increased students' interest; helped our institution to follow and discuss protocols that are already accepted worldwide; and stimulated professors to promote telemedicine-related research in their own specialties and keep up-to-date. These high-technology meetings have shortened distances in our vast country, and to other reference centers abroad. This virtual proximity has enabled discussion of international training with students and residents, to increase their overall knowledge and improve their education within this institution13013236Serviços de telessaúde e telemedicina estão avançando rapidamente, com um espectro cada vez maior de tecnologias da informação e comunicação que podem ser aplicadas de forma ampla para a saúde da população, bem como para a educação médica. O objetivo deste artigo é relatar a experiência da nossa instituição com 100 reuniões por videoconferência entre cinco diferentes países das Américas no período de um ano. Estudo retrospectivo na Universidade Estadual de Campinas. Através de um banco de dados do Microsoft Excel, foram analisadas retrospectivamente todas as conferências realizadas em nossa instituição, de setembro de 2009 a agosto de 2010, em todas as especialidades. Um total de 647 alunos, médicos e professores participaram das reuniões de telemedicina. Em média, 8,3 (± 4,3) teleconferências foram realizadas mensalmente durante o período analisado. Excluindo os feriados e o mês de inauguração do anfiteatro de telemedicina, as nossas taxas de teleconferência atingiram a média de 10,3 (± 2,7), ou duas teleconferências sobre uma média semanal. Cirurgia do Trauma e reuniões sobre segurança dos pacientes foram, de longe, os temas mais comuns discutidos em nossas reuniões de teleconferência, correspondendo por 22% e 21% do total de chamadas. Nossa experiência com as reuniões de telemedicina aumentou o interesse dos alunos, ajudou a nossa instituição a acompanhar e discutir protocolos que já são aceitos em todo o mundo e estimulou nossos professores a promover pesquisas relacionadas à telemedicina em suas próprias especialidades, mantendo-os atualizados. Essas reuniões com envolvimento de alta tecnologia encurtaram as distâncias dentro de nosso país vasto e com outros centros de referência no exterior. Esta proximidade virtual permitiu discussões com alunos e residentes sobre estágios internacionais a fim de aumentar seu conhecimento global e melhorar a sua educação dentro da própria instituiçã

Variable Attention Masking for Configurable Transformer Transducer Speech Recognition

This work studies the use of attention masking in transformer transducer based speech recognition for building a single configurable model for different deployment scenarios. We present a comprehensive set of experiments comparing fixed masking, where the same attention mask is applied at every frame, with chunked masking, where the attention mask for each frame is determined by chunk boundaries, in terms of recognition accuracy and latency. We then explore the use of variable masking, where the attention masks are sampled from a target distribution at training time, to build models that can work in different configurations. Finally, we investigate how a single configurable model can be used to perform both first pass streaming recognition and second pass acoustic rescoring. Experiments show that chunked masking achieves a better accuracy vs latency trade-off compared to fixed masking, both with and without FastEmit. We also show that variable masking improves the accuracy by up to 8% relative in the acoustic re-scoring scenario.Comment: 5 pages, 4 figures, 2 Table

The use of corticosteroid for the prophylaxis of fat embolism syndrome in patients with long bone fracture

The Evidence-based Telemedicine - Trauma & Acute Care Surgery (EBT-TACS) Journal Club conducted a critical review of the literature and selected three recent studies on the use of corticosteroids for the prophylaxis of fat embolism syndrome. The review focused on the potential role of corticosteroids administration to patients admitted to the intensive care unit (ICU) at risk of developing post-traumatic fat embolism. The first study was prospective and aimed at identifying reliable predictors, which occurred early and were associated with the onset of fat embolism syndrome in trauma patients. The second manuscript was a literature review of the role of corticosteroids as a prophylactic measure for fat embolism syndrome (FES). The last manuscript was a meta-analysis on the potential for corticosteroids to prophylactically reduce the risk of fat embolism syndrome in patients with long bone fractures. The main conclusions and recommendations reached were that traumatized patients should be monitored with non-invasive pulse oximetry and lactate levels since these factors may predict the development of FES, and that there is not enough evidence to recommend the use of steroids for the prophylaxis of this syndrome.A reunião de revista Telemedicina Baseada em Evidência - Cirurgia do Trauma e Emergência (TBE-CiTE) realizou uma revisão crítica da literatura e selecionou três artigos recentes sobre o uso de corticoide para a profilaxia da síndrome de embolia gordurosa. O foco desta revisão foi a indicação ou não do uso de corticoide nos pacientes admitidos na unidade de terapia intensiva (UTI) com risco de desenvolverem embolia gordurosa pós traumática. O primeiro artigo foi um estudo prospectivo com o objetivo de estabelecer fatores preditivos confiáveis, precoces e úteis associados ao aparecimento da síndrome da embolia gordurosa (SEG) em pacientes traumatizados. O segundo artigo foi uma revisão de literatura sobre o papel do corticoide como medida profilática à síndrome de embolia gordurosa. O último artigo foi uma meta-análise sobre a capacidade do corticoide em reduzir o risco de síndrome da embolia gordurosa nos pacientes com fraturas de ossos longos. As principais conclusões e recomendações foram que pacientes traumatizados devem ser monitorizados na UTI com oximetria de pulso e medida do lactato já que estes fatores podem predizer o aparecimento de SEG e que não existe evidência suficiente para recomendar o uso de corticoide para a profilaxia desta síndrome.42342

Artesunate ameliorates experimental autoimmune encephalomyelitis by inhibiting leukocyte migration to the central nervous system

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOExperimental autoimmune encephalomyelitis (EAE) is T-celldependent disease of the central nervous system (CNS) of mice. This model resembles multiple sclerosis (MS) in many aspects. Therapies that focus in the modulation of the immune response and cellular infiltration in the CNS present best effects in the clinics. Artesunate (Art) is a semi-synthetic sesquiterpene derivative from artemisinin and has been shown to reduce the clinical signs of autoimmune disease models through mechanisms not yet understood. In this study, we aimed to evaluate whether administration of Art would ameliorate EAE. Methods and Results: C57BL6 mice were immunized with MOG(35-55) peptide to induce EAE. At the same time, Art treatment started (3 mg/kg/day via i.p.) for five consecutive days. We found that Art treatment reduced the clinical signs of EAE and that correlated with a reduced infiltration of cells in the CNS. Disease amelioration did not correlate with immunomodulation as recall responses, leukocyte subpopulations, and gene expression analysis were similar among treated and untreated mice. Ultimately, further analysis provided data indicating that a possible mechanism of action for Art is dependent on the cellular migration to the CNS. Conclusions: Artesunate reduces the severity of EAE by inhibiting migration of pathogenic T cells to the CNS.Experimental autoimmune encephalomyelitis (EAE) is T-celldependent disease of the central nervous system (CNS) of mice. This model resembles multiple sclerosis (MS) in many aspects. Therapies that focus in the modulation of the immune response and cellula228707714FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO2014/19492-3; 2014/02631-0; 2014/11588-

A influência da obesidade no desenvolvimento do câncer de mama e em seu prognóstico em mulheres no estado de Goiás

O câncer de mama é o segundo tipo de câncer mais comum entre as mulheres. Entende- se a gênese do câncer de mama como sendo multifatorial, e sabe-se que diversos aspectos genéticos, ambientais e relacionados ao estilo de vida estão implicados em sua etiologia (CÂNDIDO, et al; 2016). A obesidade pode contribuir para o aumento da incidência do câncer de mama em todo o mundo. Contudo, as neoplasias mamárias do tipo hereditário correspondem de 5% a 10% dentre os casos de câncer de mama, sendo este grupo muito relacionado a alterações de genes supressores de tumor (SARTORI, BASSO, 2019). A influência da obesidade no câncer de mama está diretamente relacionada a possíveis desfechos insatisfatórios, possuindo riscos significativamente maiores de recorrência (PAPA, et al; 2013). Objetiva-se com esse estudo analisar a relação da obesidade com surgimento e prognóstico do câncer de mama através da análise de prontuário das pacientes do Hospital Alberto Rassi (HGG) com intuito de observar altura e peso das participantes para cálculo de IMC e entender a diferença do prognóstico de pacientes obesas e não obesas. Espera-se, com isso, identificar a relação entre o fator de risco obesidade na maior incidência do câncer de mama, além da influência do sobrepeso na piora progressiva no prognóstico e tratamento dos pacientes

Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise

The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. in the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, and the clinical score was attenuated. Although, the cytokine levels were decreased in the brain and increased in the spinal cord, BDNF was elevated in both compartments with a tendency of lesser demyelization volume in the spinal cord of the exercised EAE group compared with the unexercised. (C) 2013 Elsevier B.V. All rights reserved.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)NIHUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, Nucleo Neurociencias, BR-31270901 Belo Horizonte, MG, BrazilMinist Educ Brazil, CAPES Fdn, Programa Pos Grad Ciencias Biol Fisiol Farmacol, BR-70040020 Brasilia, DF, BrazilUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Patol, BR-31270901 Belo Horizonte, MG, BrazilUniversidade Federal de São Paulo, Dept Biofis, BR-04023062 São Paulo, BrazilUniv Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Lab Venenos & Toxinas Anim, BR-31270901 Belo Horizonte, MG, BrazilUniv Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USALa Trobe Univ, Dept Biochem, Bundoora, Vic 3086, AustraliaUniversidade Federal de São Paulo, Dept Biofis, BR-04023062 São Paulo, BrazilCAPES: BEX 0020/12-5NIH: NS051709NIH: NS065479FAPEMIG: CBB-APQ-01459-10FAPEMIG: PPM-00200-12Web of Scienc